The local names for the river include:

From Tai:

Thai: แม่น้ำโขง, [mɛ̂ː náːm kʰǒːŋ], or just 'แม่โขง' [mɛ̂ː kʰǒːŋ].

Lao: ແມ່ນ້ຳຂອງ, [mɛː nâːm kʰɔːŋ], ນ້ຳຂອງ [nâːm kʰɔːŋ].

Tai Lue: น้ำแม่ของ [nâːm mɛː kʰɔ̌ːŋ], น้ำของ [nâːm kʰɔ̌ːŋ].

Khmer: មេគង្គ Mékôngk [meːkɔŋ], ទន្លេមេគង្គ Tônlé Mékôngk [tɔnlei meikɔŋ].

Burmese: မဲခေါင်မြစ်, IPA: [mɛ́ɡàʊɰ̃ mjɪ̰ʔ].

Shan: ၼမ်ႉၶွင် [nâm.kʰɔ̌ŋ] or ၼမ်ႉမႄႈၶွင် [nâm.mɛ.kʰɔ̌ŋ].

Chinese: 湄公河; Méigōng hé.

Vietnamese: Sông Mê Kông (IPA: [ʂə̄wŋm mē kə̄wŋm]).

Other:

Vietnamese: Sông Cửu Long, (九龍 Nine Dragons River [ʂə̄wŋm kɨ̂w lāwŋm]).

Khmer: ទន្លេធំ Tônlé Thum [tɔnlei tʰum] (lit. "Big River" or "Great River").

Khmuic: [ŏ̞m̥ kʰrɔːŋ̊], 'ŏ̞m̥' means 'river' or 'water', here it means 'river', 'kʰrɔːŋ̊' means 'canal'. So 'ŏ̞m̥ kʰrɔːŋ̊' means 'canal river'. In the ancient time Khmuic people called it '[ŏ̞m̥ kʰrɔːŋ̊ ɲă̞k̥]' or '[ŏ̞m̥ kʰrɔːŋ̊ ɟru̞ːʔ]' which means 'giant canal river' or 'deep canal river' respectively